Acute febrile neutrophilic dermatosis to specific systemic factors like infection, hematologic disease, inflammation, drug exposure. Studies indicate a mixed infiltrate of histiocytic cells and poly-morphonuclear leukocytes with nuclear fragmentation in skin lesions.
Clinical Trials and Research Studies on Acute Febrile Neutrophilic Dermatosis
New York (USA), June 22, 2013
Acute Febrile Neutrophilic Dermatosis: Clinical Trials and Research Studies
Acute febrile neutrophilic dermatosis or sweet’s syndrome occurs in response to specific systemic factors like infection, hematologic disease, inflammation, drug exposure, or vaccination. It is a reactive process more affected by associated neutrophilia and in response to various medications.
Diverse granulocyte colony-stimulating factors or G-CSF support spread of lesions as they suppress apoptosis and sustain neutrophils to survive. G-CSF levels increase in people with sweet’s syndrome. Further, sometimes even when absolute count of neutrophil is low, neutrophil count in blood steadily increases. As a result, lesions continue to spread.
Studies indicate a mixed infiltrate of histiocytic cells and poly-morphonuclear leukocytes with nuclear fragmentation in skin lesions. These lesions are papillary. Swellings in few endothelial cells are visible. However, deposition of fibrin, thrombosis, immunoglobulin within the vessel walls, inflammatory infiltration of vascular walls, and red blood cell extravasations are not to be seen in skin lesions soon after they appear. Later on, lesions develop vasculitis due to prolonged exposure to numerous metabolites and toxic products are released.
Genetic linkage has been observed in a report of two Japanese brothers. Development of acute febrile neutrophilic dermatosis in neonatal stage is attributed to genetic reasons. Structural alterations in the long arm of chromosome 3 or 3q are responsible for neutrophil migration. Such changes are noted to be present in cases of sweet’s syndrome.
Acute Febrile Neutrophilic Dermatosis – Definition and Diagnosis
Definition and Diagnosis of Acute Febrile Neutrophilic Dermatosis
Acute Febrile Neutrophilic Dermatosis – Causes and Evaluation
Causes and Evaluation of Acute Febrile Neutrophilic Dermatosis
Acute Febrile Neutrophilic Dermatosis – Signs and Symptoms
Signs and Symptoms of Acute Febrile Neutrophilic Dermatosis
Acute Febrile Neutrophilic Dermatosis – Complications and Risk Factors
Complications and Risk Factors for Acute Febrile Neutrophilic Dermatosis
Acute Febrile Neutrophilic Dermatosis – Diagnostic Tests and Procedures
Diagnostic Tests and Procedures for Acute Febrile Neutrophilic Dermatosis
Acute Febrile Neutrophilic Dermatosis – Treatments and Medications
Treatments and Medications for Acute Febrile Neutrophilic Dermatosis
Acute Febrile Neutrophilic Dermatosis – Home Remedies and Alternative Therapies
Home Remedies and Alternative Therapies for Acute Febrile Neutrophilic Dermatosis
Acute Febrile Neutrophilic Dermatosis – Prevention and Coping
Prevention and Coping with Acute Febrile Neutrophilic Dermatosis
Acute Febrile Neutrophilic Dermatosis – Lifestyle Changes and Self-Help
Lifestyle Changes and Self-Help for Acute Febrile Neutrophilic Dermatosis
Acute Febrile Neutrophilic Dermatosis – Prevention, Treatment, and Remedies
Acute Febrile Neutrophilic Dermatosis – Causes, Symptoms, Diagnosis, Prevention, Treatment, and Remedies